Картинки на тему «C.R.E.D.O. Clopidogrel for the Reduction of Events During Observation» |
Курсы английского | ||
<< Low-level techniques applied in experiments looking for rare events | Иксрей 23 апреля 2015 >> |
![]() C.R.E.D.O. Clopidogrel for the Reduction of Events During Observation |
![]() C.R.E.D.O |
![]() C.R.E.D.O |
![]() C.R.E.D.O |
Автор: Martini Giovanni --Quadra 950. Чтобы познакомиться с картинкой полного размера, нажмите на её эскиз. Чтобы можно было использовать все картинки для урока английского языка, скачайте бесплатно презентацию «C.R.E.D.O. Clopidogrel for the Reduction of Events During Observation.ppt» со всеми картинками в zip-архиве размером 719 КБ.
Сл | Текст | Сл | Текст |
1 | C.R.E.D.O. Clopidogrel for the | 12 | C.R.E.D.O. Death, MI and Stroke at 1 |
Reduction of Events During Observation. | Year. P=.02. 10.5%. -26%. 8.5%. 15. 10. 5. | ||
Multicenter Multinational (USA, Canada) | Clopid. 1 Mth. Clopid. 1 Year. 0. 0 3 6 9 | ||
Prospective Randomized Double Blind | 12 Mths. Combined EndPoint Occurrence (%). | ||
Placebo Controlled Trial. From Steinhubl | 13 | C.R.E.D.O. Death, MI, Stroke at 1 Year | |
et al, JAMA 2002;228:2411-20. | in Key Subgroups. 0 1/2 4 24 48 Hrs. | ||
2 | C.R.E.D.O. Aim of the Study. Safety | 14 | C.R.E.D.O. 1 Year Primary and |
and efficacy of a loading dose of | Secondary Prespecified EndPoints. Death MI | ||
Clopidogrel prior to elective PCI Safety | Stroke TVR. 1 Year Clopidogrel. 1 Month | ||
and efficacy of 1 Year vs 1 Month combined | Clopidogrel. 13.6. 13.1. 8.4. 6.7. 2.3. | ||
treatment with Clopidogrel 75 mg + ASA | 1.7. 0.9. 0.9. | ||
after elective PCI. | 15 | C.R.E.D.O. Major Bleedings. 8.8. 6.7. | |
3 | C.R.E.D.O. Inclusion Criteria. Pts | 4.8. 3.8. 28 Days 1 Year. More than ? of | |
with symptomatic CAD scheduled for PCI | major procedural bleedings due to CABG. P | ||
without contraindications to | = 0.24. P = 0.07. Loading Dose-1 Year | ||
antithrombotic or antiplatelet treatment | Clopidogrel. 1 Month Clopidogrel. | ||
or stent implantation and with no ST | 16 | C.R.E.D.O. Conclusions. Prolongation | |
segment elevation within 24 hrs or planned | of treatment with an ADP inhibitor such as | ||
staged procedures or recent (<7 days) | clopidogrel beyond 1 month after | ||
administration of GP IIb-IIIa inhibitors, | PCIreduces the incidence of death/MI at 1 | ||
clopidogrel or thrombolytics. | year There is a strong trend to reduction | ||
4 | C.R.E.D.O. 3-24 hrs before PCI. 28 | of death/MI/urgent TVR at 28 days after a | |
Days and 1 Year Clinical Follow-Up. 300 mg | loading dose of 300 mg of clopidogrel | ||
Clopidogrel Loading Dose + ASA 325 mg. | administered at least 6 hrs before PCI. | ||
Placebo + ASA 325 mg. 75 mg Clopidogrel + | 17 | C.R.E.D.O. Questions and Criticisms. | |
ASA 325 mg for 1 Year. Placebo + ASA 325 | Did pretreatment interfere with long-term | ||
mg for 1 Year. GP IIb-IIIa Inhib. (mainly | results? Did the poor compliance to | ||
Abciximab) on prespecified or Bail-out | long-term treatment with clopidogrel (only | ||
Indications. Clopidogrel 75 mg + ASA 325 | 63/61% of pts took the study drug) modify | ||
mg for 1 Month. | results? Can we improve it? Can we reduce | ||
5 | C.R.E.D.O. Outcomes. At 28 Days Death, | the excess of bleeding? | |
MI, Urgent TVR in the per protocol | 18 | Aspirin Dose and Bleeding Events in | |
population (all pts undergoing PCI) with | CURE. 12563 Pts with non-ST Elevation ACS. | ||
prespecified secondary analysis of pts | Major or Life Threatening Bleeding Events. | ||
receiving clopidogrel loading dose or | Aspirin Alone (p=0.057). | ||
placebo <6 hrs or >6 hrs before PCI | Aspirin/Clopidogrel (p=0.042). 4.63. 4.64. | ||
At 1 Year Death, MI, Stroke with | 3.77. 3.32. 3.19. 2.82. 2.24. 1.92. ASA | ||
prespecified secondary endpoints of TVR. | <100 mg 100-150 mg 150-300 mg >300 | ||
6 | C.R.E.D.O. Power Calculation based on | mg. From Peters et al EHJ | |
a Retrospective Analysis of 2450 Pts in | 2002;Suppl.4:510. | ||
the EPISTENT trial: 28 Days Events. | 19 | C.R.E.D.O. Will a higher loading dose | |
P<0.01. From Steinhubl et al, JACC | help? 10 + 10 Pts pretreated with 200 mg | ||
1998;32:1366-70. 13.4%. 8.9%. 7.5%. No | Aspirin. 0 1/2 4 24 48 Hrs. From Muller et | ||
Ticlopidine Ticlopidine Expected Pre-PTCA | al, Heart 2001;85:92-93. ADP 20 | ||
Pre-PTCA for Clopid. Loading (expected | ?mol-induced Aggregation. | ||
placebo) Dose + 1 Year. | 20 | C.R.E.D.O. Do we still need IIb-IIIa | |
7 | C.R.E.D.O. Clinical Characteristics | inhibitors in pts with effective | |
(I). Clopidogrel Loading Dose + | clopidogrel pretreatment? ISAR- REACT: | ||
Clopidogrel 1 Year N= 1053. Placebo | after 600 mg loading dose Clopidogrel: | ||
Loading Dose + Clopidogrel 1 Mo N= 1063. | Randomization to Abciximab or Placebo. | ||
Age (yrs) 61+5 62+7 NS Male Sex (%) 70.7% | 21 | TOPSTAR Study. 109 Pts with 375 mg | |
72.1% NS Diabetes (%) 27.5% 25.4% NS | Clopidogrel and 500 mg ASA 24 Hrs before | ||
Statins (%) 53.6% 57.5% p=0.07 Ca++ Chan. | PCI. From Bonz et al, JACC 2002;40:662-8. | ||
Block. (%) 25.5% 29.4% p=0.08 MI 14.3 13.1 | Tirofiban 10 ?g + 18 Hrs Infusion. Placebo | ||
Indication (%) UAP 52.5 53.1 NS SA 32.8 | bolus + 18 Hrs infusion. 128. 108. 100. | ||
32.8 PTCA 85.6 86.2 Treatment (%) Medical | 100. 98. 87. % Platelet Function. 14. 10. | ||
8.3 7.6 NS CABG 3.9 4.0. | Prior 30 min 12 Hrs 48 Hrs. | ||
8 | C.R.E.D.O. Clinical Characteristics | 22 | TOPSTAR Study. 109 Pts with 375 mg |
(II). Received >1 Stent (%) 89.7 88.3 | Clopidogrel and 500 mg ASA 24 Hrs before | ||
NS Total Stent Length (mm) 24.4 23.5 NS GP | PCI. 63%. 40%. Positive Troponin T | ||
IIb-IIIa Antag. (%) 47.4% 43.3% p=0.08. | (>0.01 ?g/ml). From Bonz et al, JACC | ||
Clopidogrel Loading Dose + Clopidogrel 1 | 2002;40:662-8. Tirofiban 10 ?g + 18 Hrs | ||
Year N= 900. Placebo Loading Dose + | Infusion. Placebo bolus + 18 Hrs infusion. | ||
Clopidogrel 1 Mo N= 915. | 23 | C.R.E.D.O. Is 1 Year Treatment Enough? | |
9 | C.R.E.D.O. Death, MI and Urgent TVR at | CHARISMA: 15000 Stable Angina Pts with 42 | |
28 Days. NS. 8.3%. -18.5%. 6.8%. 10. 8. 6. | Mths F-Up. 2658 Pts undergoing PCI in the | ||
Clopid. No Loading. 4. Clopid. Loading. 2. | CURE trial. From Metha et al, Lancet | ||
0. 0 Days 7 14 21 28. Combined EndPoint | 2001;358:527-33. Death, MI Kaplan-Meier | ||
Occurrence (%). | cum. Hazard rates. | ||
10 | C.R.E.D.O. Death, MI and Urgent TVR at | 24 | C.R.E.D.O. Questions and Criticisms. |
28 Days. P=0.051. -38.6%. 10. 8. 6. 4. | What about cost-effectiveness? Mechanism | ||
Clopid. No Loading. Clopid. < 6 Hrs | of clinical benefit? prevention of | ||
Loading Clopid. > 6 Hrs. 2. 0. 0 Days 7 | periprocedural damage, TVR late events and | ||
14 21 28. Combined EndPoint Occurrence | non TVR late events Long-term treatment | ||
(%). | with clopidogrel advised for pts who | ||
11 | C.R.E.D.O. Death, MI, Urgent TVR at 28 | receive drug eluting stents (3 mths | |
Days. | SIRIUS, 6 mths TAXUS). | ||
C.R.E.D.O. Clopidogrel for the Reduction of Events During Observation.ppt |
«The animals» - The animals which live in the polar regions. FISH. POLAR BEAR. FLAMINGO. STARFISH. REINDEER. The animals which live in the OCEAN. KOALA. SEAL. CAMEL. PENGUIN. WOMBAT. GIRAFFE. The animals which live in a SAVANNA. ELEPHANT. PANDA. The animals which live in Australia. BOBCAT. SCORPIO. EMU. GRIFFIN. ZEBRA.
«Женщина the woman» - As great a pity to see a woman cry as a goose go barefoot. От нашего ребра нам не ждать добра; «Un homme»- франц. « A man »- англ. The wife is the key to the house. Chicken’s mind- Куриные мозги. « Der mann»- нем. Пословицы. A woman’s tongue wags like a lamb’s tail. Пути пополнения лексической группы «женщина» в английском языке.
«English for you» - При выполнении заданий программа оценивает твой результат и предоставляет отчёт. ENGLISH FOR YOU. Узнать насколько хорошо ты усвоил материал тебе помогут: Ты научишься правильно строить предложение. Все слова и выражения озвучены носителями языка. Артикль Множественное число Предлоги. Что ты научишься делать и узнаешь.
«The green movement» - The main objective — to achieve the decision of global environmental problems, including by attraction to them of attention of the public and the authorities. Green color which is used by participants of movement as the general emblem, serves as a symbol of the nature, hope and updating. National offices Green Peace are opened in 43 countries of the world as the independent units working over achievement of the purposes of the national projects.
«The english-speaking countries» - USA. Disneyland. The English-speaking countries. Great Britain. Australia. Scotland.
«Курсы английского Success English» - Золотой сертификат. Модуль четвертый. Модуль второй. Разговорный английский язык. Быстрое изучение английского языка. Бронзовый сертификат. Взаимодействие с англоязычной культурой. Сертификаты Success English. Деловой английский язык. Взаимодействие с носителями языка. Описание курса. Модуль третий.